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Publications by Zora Scientists

2011


Hoeks J, Mensink M, Hesselink MK, Ekroos K, Schrauwen P. Long- and Medium-Chain Fatty Acids Induce Insulin Resistance to a Similar Extent in Humans Despite Marked Differences in Muscle Fat Accumulation
J Clin Endocrinol Metab. 2011 Oct 26. [Epub ahead of print]


Jung HR, Sylvänne T, Koistinen KM, Tarasov K, Kauhanen D, Ekroos K. High throughput quantitative molecular lipidomics Biochimica et Biophysica Acta (BBA), Article in press, Available online July 2011

Schunkert H. et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease Nature Genetics, 2011;  43(4): 333-340.

Perman JC. et al. The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction J Clin Invest. 2011; 121(7): 2625-2640.

2010


Ekroos K, Jänis M, Tarasov K, Hurme R, Laaksonen R  Lipidomics: A Tool for Studies of Atherosclerosis Current Atherosclerosis Reports, 2010; 12(4): 273-281

Teslovich, TM et al. Biological, clinical and population relevance of 95 loci for blood lipids Nature, 2010; 466(5): 707-713

2009 


Ejsing CS, Sampaio JL, Surendranath V, Duchoslav E, Ekroos K, Klemm RW, Simons K, Shevchenko A. Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry Proc Natl Acad Sci USA. 2009 Jan 27.

Ståhlman M, Ejsing CS, Tarasov K, Perman J, Borén J, Ekroos K. High-Throughput Shotgun Lipidomics by Quadrupole Time-of-Flight Mass Spectrometry Journal of Chromatography B. 2009 

Sergent O, Ekroos K, Lefeuvre-Orfila L, Rissel M, Forsberg G-B, Oscarsson J, Andersson TB,Lagadic-Gossmann D. Ximelagatran increases membrane fluidity and changes membrane lipid
composition in primary human hepatocytes
Toxicology in Vitro, 2009 Jul 16.

Hiukka a. et al. ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan Diabetes, 2009; Vol 58, 2018 - 2026

 2008


Ekroos, K. Unraveling glycerophospholipidomes by lipidomics, in “Biomarker methods in drug discovery and development, Methods in pharmacology and toxicology”
Humana Press, 2008.

Tarassov K, Messier V, Landry CR, Radinovic S, Molina MM, Shames I, Malitskaya Y, Vogel J, Bussey H, Michnick SW. An in Vivo Map of the Yeast Protein Interactome
Science (2008); 320: 1465-1470.

Orešič M, Simell S, Sysi-Aho M, Näntö-Salonen K, Seppänen-Laakso T. et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes
JEM (2008) 205, No. 13, 2975-2984.

Jänis MT, Laaksonen R, Orešič M.  Metabolomic strategies to identify tissue-specific effects of cardiovascular drugs
Expert Opin. Drug Metab. Toxicol. (2008) 4(6):665-680.

2007


Lelliott CJ, Ljungberg A, Ahnmark A, William-Olsson L, Ekroos K, Elmgren A, Arnerup G, Shoulders CC, Oscarsson J, Lindén D. Hepatic PGC-1β over-expression induces combined hyperlipidemia and modulates the response to PPARα Activation.
Arterioscler Thromb Vasc Biol. (2007) 27, 2707-2713.

Schick B, Laaksonen R, Frohlich J, Päivä H, Lehtimäki T, Humphries KH, Côté H. Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin
Clin Pharmacol Ther (2007);81(5):650-3.

 2006


Lindén D, William-Olsson L, Ahnmark A, Ekroos K, Hallberg C, Peilot-Sjögren H, Becker B, Svensson L, Clapham JC, Oscarsson J, Schreyer S. Liver directed overexpression of mithocondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triglyceride secretion and reduced fatty acid oxidation
FASEB J. 20(3):434-43 (2006).

Laaksonen R, Katajamaa M, Päivä H, Sysi-Aho M, Saarinen L, Junni P, Lütjohann D, Smet J, Van Coster R, Seppänen-Laakso T, Lehtimäki T,  Soini J, Orešič M. A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin induced changes in muscle
PLoS ONE 1(1): e97 (2006).

Eising CS, Duchoslav E, Sampaio J, Simons K, Bonner R, Thiele C, Ekroos K, Shevchenko A. Automated identification and quantification of glycerophospholipid molecular species by multiple precursor ion scanning
Anal Chem. (2006) Sep 1;78(17):6202-14.

Campbell-Valois FX, Tarassov K, Michnick SW. Massive sequence perturbation of the Raf ras binding domain reveals relationships between sequence conservation, secondary structure propensity, hydrophobic core organization and stability
J Mol Biol. 8;362(1):151-71(2006).

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